Butyrylcholinesterase for protection from organophosphorus poisons: Catalytic complexities and hysteretic behavior
نویسندگان
چکیده
منابع مشابه
Human Serum Butyrylcholinesterase: A Bioscavenger for the Protection of Humans from Organophosphorus Exposure
Human serum butyrylcholinesterase (Hu BChE) is currently under advanced development as a pretreatment drug for organophosphate (OP) poisoning in humans. Toward this effort, a procedure for the large-scale purification of Hu BChE from Cohn fraction IV-4 was developed, its pharmacokinetic properties were established, its shelf life was evaluated at various temperatures, and its safety and efficac...
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We report here our preliminary results on the use of catalytic antibodies as an approach to neutralizing organophosphorus chemical weapons. A first-generation hapten, methyl-alpha-hydroxyphosphinate Ha, was designed to mimic the approach of an incoming water molecule for the hydrolysis of exceedingly toxic methylphosphonothioate VX (1a). A moderate protective activity was first observed on poly...
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Organophosphorus (OP) insecticides and chemical warfare agents act primarily by inhibiting acetylcholinesterase. There are many secondary targets for OP toxicants as observed for example with the major insecticide chlorpyrifos and its bioactivated metabolite chlorpyrifos oxon (CPO). Therefore, it was surprising that the predominant mouse brain protein labeled in vitro by [(3)H-ethyl]CPO (1 nM) ...
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BACKGROUND The usefulness of a low butyrylcholinesterase (BuChE) activity on admission for predicting severity in acute organophosphorus (OP) insecticide poisoning has long been debated. Previous studies have been confounded by the inclusion of multiple insecticides with differing inhibitory kinetics. AIM We aimed to assess the usefulness of admission BuChE activity, together with plasma OP c...
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ژورنال
عنوان ژورنال: Archives of Biochemistry and Biophysics
سال: 2010
ISSN: 0003-9861
DOI: 10.1016/j.abb.2009.12.005